Sepracor - Journal Publications: LUNESTA(R) (eszopiclone)

1. Bech P, Wilson P, Wessel T, Lunde M, Fava M. A validation analysis of two self-reported HAM-D6 versions. Acta Psychiatrica Scandinavica 2009;119(4):298-303.

2. Jia F, Goldstein PA, Harrison NL. The modulation of synaptic GABAA receptors in the thalamus by eszopiclone and zolpidem. Journal of Pharmacology and Experimental Therapeutics 2009;328(3):1000-1006.

2007 LUNESTA (eszopiclone) Publications

1. Krystal A, Fava M, Rubens R, Wessel T, Caron J, Wilson P, Roth T, McCall WV. Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression. Journal of Clinical Sleep Medicine 2007; 3(1):48-55.

2. Ozminkowski RJ, Wang S, Walsh JK. The direct and indirect costs of untreated insomnia in adults in the United States. SLEEP 2007;30(3):263-273.

3. Roth T, Roehrs T, Pies, R. Insomnia: Pathophysiology and implications for treatment. Sleep Medicine 2007;11:71-79.

2006 LUNESTA (eszopiclone) Publications

1. Fava M, McCall WV, Krystal A et al. Eszopiclone Co-Administered With Fluoxetine in Patients With Insomnia Coexisting With Major Depressive Disorder. Biol Psychiatry 2006, 59(11):1052-1060.

2. Fava M, McCall V, Krystal A et al. Eszopiclone co-administered with fluoxetine for insomnia co-existing with Major Depressive Disorder (MDD): analysis by severity of depression. Abstracts of the 46th Annual NCDEU Meeting. 2006.

3. McCall WV, Erman M, Krystal AD, Rosenberg R, Scharf M, Zammit GK, Wessel T. A polysomnography study of eszopiclone in elderly patients with insomnia. Current Medical Research and Opinion 2006, 22(9):1633-1642.

2005 LUNESTA (eszopiclone) Publications

1. Rosenberg R, Caron J, Roth T, Amato D. An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults. Sleep Medicine 2005:6:15- 22.

2. Scharf M, Erman M, Rosenberg R, Seiden D, McCall WV, Amato D, Wessel TC. A 2-week efficacy and safety study of eszopiclone in elderly patients with primary insomnia. SLEEP 2005; 28(6):720-727.

3. Tarantino P, Appleton N, Lansdell K. Effect of Trazodone on hERG channel current and QT-interval. European Journal of Pharmacology 2005; 510:75-85.